CB-6644 OPTIONS

TAK-243 preferentially certain to UBA1 in excess of the linked E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 decreased amounts of ubiquitylated proteins, greater markers of proteotoxic pressure and DNA hurt anxiety. In vivo, TAK-243 decreased leukemic burden and targeted leukemic stem cells with out proof of t